It's possible to breed half-litter mates....it's called line breeding which many breeders do in order to "set type" ...but..only after a long & careful study of each dog's bloodlines, pedigreed ancestors, phenotype (the dog you actually see) and genotype ( what you don't see that's lurking in the dog's genetic makeup of his ancestors) Actually, all "line breeding" is a form of "in-breeding' ..it's just the intensity that differs...full brother & sister being the most intense form of inbreeding..& totally unrelated dogs ( with no common ancestors in the last 3 generations) being an "out cross" which can, in many cases, be just as unpredictable in the outcome of the offspring, in the game of genetic roulette!
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