First thing I'll ask is, is she fixed? If not, she could be becoming physically mature now and has the urge to mark her territory in your house. This is more common in males than females but it can certainly be an issue with females as well.
Any chages like a new pet, new schedual, etc around the time she started doing this?
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Dogs that chase cars have learned that cars run away. This behavior is reinforced each time he chases one away.
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