Dogs and cats can certainly have a localised reaction to vaccines(or any injection) however it would only occur at the sight where the vaccine was given and would happen within one week of the injection.A soft mobile mass on the leg could be a tumour either malignant or not. Lipomas are benign tumours that develop on dogs, they usually develop slowly over months to years. However a fast growing mass would usually indicazte something more serious. Watch the mass and if it grows rapidly or changes in anyway take to vet for a fine needle aspirate to be taken and they will look at the cyctology of it under microscope. If it looks fatty it will be a lipoma and no need to worry unless it causes trouble for your pet, however if they see cells they will need to send the cytology sample to a pathologist so that they can work out what kind of mass it is and whether surgery is required.If I was you (and this is what I would tell clients) watch for 1-2 weeks if changes occur in size, shape or the skin near it then bring in, if not keep watch and get it looked at at next vaccination.
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