[Lara's mom]

Don't blame yourself. You trusted your vet. You are supposed to be able to do that. Unfortunately, I think a lot of vets today are "in bed" with the pharmaceutical companies which is beyond contemptible. What happened is NOT your fault. I'm so very sorry for your loss.

[cherylmartin]

We dog lovers who have lost our 'child' must contact: Pegasus Laboratories via their webpage and tell THEM your story. They make the junk. If they don't know it's killing our 'furbabies' then they will continue to make it. Flood them with emails-ask all those from this website to email them. It won't take much of your time, but for my Jasmine and others who left this earth too early, only WE can stop the making of this drug.

[CadburysMum]

Wow, I just looked Proin up as my 15 year old Choc lab was peeing all over the place and was just prescribed it, this site was one of the first to come up on Google.
He has been on it for two days and wont stop panting and pacing. I called the vet, they said to lower the pills from 3 a day to two a day, I think after reading these posts that he wont be taking any more at all. I am so sorry to those who have lost your dogs, how terrible I feel awful, I could have perhaps killed my best friend of 15 years....thanks for all the info.

[cherylmartin]

I hope you have stopped it in time. Pegasus Lab wrote me that there was NO proof that ProIn caused the death of Jasmine. All I can say to that is I KNOW how she was before she took it-I KNOW how she acted when she took it-I KNOW what happened to her. The FDA states on its website that THEY WANT to know of any and all adverse reactions to drugs to animals. I am going to let them know what I observed in my Jasmine. You can report this annonismously. I hope all those who have been effected by ProIn will do the same. One voice is not enough to let the FDA know-one voice is not enough!

[CadburysMum]

He had his last pill yesterday and panted and paced into the evening, this morning he seems fine, he only took 5 pills in all, and although my Vet said to reduce the dosage, I have decided to discontinue giving it to him, I have had this dog for a 1/3 of my life, he has seen me through many life changes and has been my constant friend. I would rather put him in doggie diapers and use extra blankets than to see him in distress, I am so grateful to the people that posted on here so I could make a somewhat informed decision and maybe saved the life of my dog.

[CorkyMax]

Thank you for taking your dog off that killer!! I just wish this message on Proin was seen by all dog lovers! Let everyone you know about this crap get the message.

[CorkyMax]

Does anyone know if it is safe to give Proin, phenylpropanolamine HCl,
to a dog that has fairly severe pulmonary hypertension? My dog's vet prescribed some today but just wanted to get second opinion. She is on lasix but nothing else for the pulmonary hypertension.

cgg Posted: Tue Aug 04, 2009 5:51 am
Post subject:

I'd certainly ask the vet to look into it.

Quote:
Side Effects

The most common side effects are pale gums, and difficulty urinating. More rarely, Proin causes restlessness, excitability, irritability, hypertension, anorexia or decreased appetite. The chance of hypertension occurring is greater if Proin is given together with non-steroidal anti-inflammatoriy drugs (NSAIDs), or with reserpine, tricyclic antidepressants, amitraz (the active ingredient of the Preventic tick control collar and canine Promeris, a flea control product), or ganglionic blocking agents. Proin can also cause ill effects in animals with preexisting conditions such as glaucoma, prostatic hypertrophy, hypertension, hyperthyroidism, diabetes mellitus, and cardiovascular disorders, or if administered in conjunction with other sympathomimetic drugs such as ephedrine or epinephrine.

jasminesmom
Post subject: Re: Proin

I hope you did not give ProIn. My Jasmine took it for 3 days, stopped eating, developed kidney failure and passed 9-04-09. It is really terrible stuff-it used to be known as Dexatrim and they took that off the market for humans. Let me know how shes doing please
If your dog has ANY underlying health issue they will suffer deadly side effects. Dexatrim was causing stokes in young women, so they took if off the market. ProIn, caused my Jasmine to stop eating and it caused kidney failure and she suffered from July 23, 2009 (her first does) until she passed 9-04-09. Please find another way to stop incontinenece

Corky/Max: I came across this forum after putting--Proin/adverse reactions in my browser. I hope Jasminesmom doesn't mind me
adding this 'conversation' to this forum! I wanted everyone to see the 1st post with the question and your answer here because of the sentences especially--to be aware of the 'alias' name for Proin and that it caused
strokes in young women!

Corky/Max: Does this not show you that because the pharmaceutical companies can no longer make money off of humans--It gets passed to our poor innocent dogs so the money keeps coming in!!

[cherylmartin]

You may use anything I have to say about ProIn for I am only speaking from my experience. I heard from Pegasus Lab today and after talking with my vet concluded that ProIn did not cause her death. Well I tend to disagree. Jasmine was healthy since pancreatits in 2006! Took ProIn developed kidney failure then she was gone. The only way we can stop this is for all effected by ProIn to contact Pegasus Las via their web site and let FDA know of side effects-I'm doing that next.

[CorkyMax]

went and told the vet of the side effects Jasmine was having, loss of appetite after the first dose-her remark to me was that she knew of no side effects. Well after some other things that transpired, I changed vets. The week after Jasmine passed I was able to sit down and write the vet and showed her what I saw at Pet Meds and other sites, indicating the side effects and most importantly it was not to be given if heart conditions present. Jasmine's heart murmur was a 4 out of 10 the day I went in to get something for incontinence ProIn so to me that's a heart condition. Ya know even a phone call saying I'm sorry would be nice.

Copied and pasted this here because--A lot of dogs have heart mur-murs--Both of mine do. And if your vet doesn't check for this there are prob. a lot of dogs that have it and you wouldn't even know about it unless your dog had it well advanced as eairlier stages/grades are not that noticeable! And I also wonder why so many dogs have mur-murs!! Even wondering if it has to do with too much stress on their immune systems from too many vaccinations and the bad, deadly prescriptions and the crappy commercial dog food they are fed that is slowly starving them from proper nutrition. The vet actually told me that it isn't uncommon for dogs to develop mur-murs almost as if it is expected!!! But why!!?? At least I know my 2 don't get commercial dog food--They are raw-fed and some home-cooking! I have said this many times--I feel so sorry for poor innocent dogs who depend on us to take good care of them! They are bombarded from every direction by greedy pharmeceutical co; unfit dog food; greedy or ignorant vets (kept in the dark--schooled by the 2 above mentioned. And then there are some good vets that have lost their license because they dared to disagree with the 2 above mentioned companies. This world is definitely run by greed!!!

[cherylmartin]

Well when my vet: 1) knowlingly gave ProIn to Jasmine, with a heart murmur and it clearly stated do not give if heart condition and when she 2) gave her diatro (Lomotil not approved by FDA for use in animals but vets CAN still write prescriptions) for diarehha and my new vet saw where it is not to be given to dogs with kidney failure. I believe vets need to be made accountable just like human doctors. I intend to file a complaint with the DVM in Georgia.

[CorkyMax]

Originally Posted by cherylmartin

Well when my vet: 1) knowlingly gave ProIn to Jasmine, with a heart murmur and it clearly stated do not give if heart condition and when she 2) gave her diatro (Lomotil not approved by FDA for use in animals but vets CAN still write prescriptions) for diarehha and my new vet saw where it is not to be given to dogs with kidney failure. I believe vets need to be made accountable just like human doctors. I intend to file a complaint with the DVM in Georgia.

No sense in me repeating the things I just posted, BUT I plan on bringing this thread to the forefront about once a week to make sure anyone who comes in this forum sees it! Should do the same for Rymadyl too. Too bad that these subjects aren't a permanent 'fixture' on the 1st page of this forum so that anybody even just entering the forum will learn about them!

[cherylmartin]

I just wish I could get those affected by ProIn to follow my steps and report it, from Pegasus Lab to the FDA! It won't cost a thing and I know my Jasmine is worth the effort and my time.

[cherylmartin]

Important Information

If you do not file a complaint with the FDA.....
you're giving the manufacturer ammunition to use against you.
They can then claim there are so few cases of adverse reactions.... nothing needs to be done.

When you don't file, you stack the statistics in the manufacturers favor.
Don't depend on your vet's office

I saw this: FDA Suspect ADE )
while searching other forums.

PLEASE if your pet has had an adverse reaction to ProIn or any other drug , contact the FDA. If you don't, the drug companies win. Do it for your lost baby.

If you want further info on how to do this, just email me.

[cherylmartin]

Dear Jasmine, my baby girl

--------------------------------------------------------------------------------

Dear Jasmine,
Today marks 30 days without you in our lives. I still weep for you. I still look at the backdoor to see if you are watching me as I work in the flower gardens. I have to stop myself from asking if you want to 'go' when we run an errand. I am still getting up at 5:30 AM to feed you and checking the clock to see if it's close to 2:00 PM yet. I still have not been able to go for our evening walk-it's just too hard to do this without you. I still look for you when we go to bed. I am keeping my promise that I made to you. Our letter to the FDA about the drug that killed you is ready to mail. Our letter to the DVM board is going then also. The guilt I still have for giving you that first dose of ProIn weighs heavy on my heart. I am so sorry I made you take it but I trusted the Vet and thought it was what you needed. I will never begin to forgive myself. I hope you have forgiven me for what I had to do Sept 4, 2009. You were just so sick. You looked so unhappy. You had not eaten anything for 3 days. Not chicken, not steak, nothing. You would not even drink water when I offered it to you. Hope it's OK that I gave your food and cookies to a 'no kill' shelter. I have kept your toys and favorite blanket. We just miss you so much Jas. You became my child when the other 2 legged children left home. Please take care my baby girl and I hope you have found Hambone, Shakes and Budley at The Rainbow Bridge. Play, eat, run and chase lizards for us. I also hope that you see the candle I light for you every Monday night.
We will always love you and miss you and you will be in my heart for eternity.
Love,
Mom

[CorkyMax]

I had stated in this thread that I was going to bring it to the surface about once a week----It is important that everyone who has a dog or knows of others who have dogs to be aware of this killer-Proin!!! It can kill your dog after only 1 dose!!! Also put Rimadyl/adverse reactions in your browser and/or put Rimadyl in the search field in this forum--the blue strip across the page--near the top of page. Another killer of dogs!! Thanks Cheryl for posting here just now and keeping this thread alive! This thread has been viewed by 25,771 people---which is a lot but I wish everyone in the world knew about the Proin and the Rimadyl and that they should be taken off the market!! How any VET could even prescribe these killers is beyond me. I know too many are ruled by the pharmeceutical companies, not to mention the commercial dog food companies!! There are vets that have lost their license because they dared go against these greedy companies. But where are their consciences!! Of course there are some greedy vets too who don't give a d--n about your dog--just lining their own pockets. And there are some who may be brainwashed too!!
----I feel so sad about what has happened to all the dogs mentioned in this thread---Lets try and stop it from happening to any more dogs. And your last post here, Cheryl brought tears to my eyes, but I'm glad you posted it as it may help save other dogs.

[Vajia]

thanks for all information about Proin. I have just got it on my dog for 2 days. I am glad I found this thread.
My baby Vajia is a 11 year old male German shepherd. He has been eating less and lost wight for about a week and then has the leaking problem. His Vet did the blood work with another exams and told me everything is fine and Rx'd Proin 50, 2 tables per day . I started to feed him one pill two days ago, last night, after the 3rd pill, he was not able to sleep, walked around in the house, and throw up. I stopped giving him this morning and searched online about the drug, found all your experience about it.

Thanks to you all for sharing this! and thanks to whoever keep the thread on the top of GooGL search!

[cherylmartin]

I sincerely hope your fur baby is one of the lucky ones and suffers no bad effects from being on ProIn for just a few days. I am also glad for you that you researched it . Umfortunately I did not. Kepp us informed as to how he is progressing.

[islandgirl45]

Originally Posted by cherylmartin

Important Information

If you do not file a complaint with the FDA.....
you're giving the manufacturer ammunition to use against you.
They can then claim there are so few cases of adverse reactions.... nothing needs to be done.

When you don't file, you stack the statistics in the manufacturers favor.
Don't depend on your vet's office

I saw this: FDA Suspect ADE )
while searching other forums.

PLEASE if your pet has had an adverse reaction to ProIn or any other drug , contact the FDA. If you don't, the drug companies win. Do it for your lost baby.

If you want further info on how to do this, just email me.

Hi, I have an 11-year-old spayed Standard poodle who has been experiencing some wet spots while sleeping and drips when she gets up from sleep. My vet prescribed two 50mg tablets of Proin a day and I picked it up Friday and began giving it to her. I just now looked up info on the medication and came across this thread. Caitlin is like my child, so I am very concerned.

I saw a January 2009 post from someone named dkraut who said she began giving her dog just 1/2 tablet once a day for about a week, then tapered off to half tablet every 2 to 3 days, which cleared up her dog's incontinence without any side effects.

I haven't seen any side effects in my Caitlin, but I'm going to try that greatly reduced dosage on her.

Meanwhile, has anyone tried out any natural alternative medications to Proin or anything that doesn't produce side effects and alleviates their pet's incontinence? Can you recommend something else?

Thanks.

[CorkyMax]

Have books on Natural Dog Care. Will print out here a chapter called: Bladder-Control Problems. This book is 10 years old and I can't vouch for anything as I have never had this problem with my 2 dogs, but figured there might be a better solution here than using 'killer Proin!' This will take some time and will be in 2-3 separate posts so 'keep tuned'--Will try to do it all today/tonight.
THE CAUSE: Dogs are reluctant to urinate in areas where they play or sleep. But despite their best intentions, even well-trained dogs may lose control occasionally or for prolonged periods of time.
---Spayed female dogs are the ones most likely to have problems with bladder control because they produce so little estrogen, a hormone that gives tension to the urinary sphincter (the muscle that controls urination), says a holistic vet. Urinary tract infections, which are readily treated with antibiotics, can also cause a loss of control. In addition, older pets, both males and females, sometimes forget their training or loss control.
---Conventional vets sometimes control problems by giving dogs a form of synthetic estrogen called diethylstilbestrol or an over-the-counter "diet" medication that strengthens and tightens the urinary sphincter. Nature has provided many sources of estrogen, however, so it isn't always necessary to resort to drugs. It is possible to use home remedies to help your dog produce more estrogen naturally. Here are a few things you may want to try.

THE SOLUTIONS:
Restore control with acupressure.----There are several acupressure points that control the bladder as well as the adrenal glands. Pressing these points may strengthen the urinary splincter and help the body produce more estrogen. The acupressure points for bladder control include the following.

1.-BL67, located on the outside edge of the outside toe on each rear foot.

2.-BL1, located on the inside corner of each eye.

3.-SP6, located on the inside rear leg above the hock (the ankle).

4.-SP10, located just above the bend on the rear knee.

---Put pressure on each of these points for about 60 seconds (1 min.), two or three times a day. Once your dog regains control, repeat the treatments once or twice a week.

Rebalance the body.----Some holistic vets treat bladder-control problems with a homeopathic combination called, appropriately enough, Urinary Incontinence. It contains healing amounts of Gelsemium, Alumina, Plantago, Causticum, and Cantharis, and it helps change your dog's hormonal balance so that the bladder and urinary sphincter work more efficiently. The vet recommends giving half a dropperful of the remedy twice a day until things start to improve.-----------post #2 to follow---------------->

[CorkyMax]

Replace Estrogen with Glangular Supplements. Dogs with bladder-control problems may improve when given supplements containing extracts from the ovaries and adrenal, thyroid, and pitituary glands. Called raw-gland concentrates or multiple-glandular dietsry supplements, these products help the body produce more natural estrogen.
---Holistic vets sometimes use a product called Symplex F, available from vets only, which contains all the necessary extracts. Or you can use a glandular supplement designed for humans, such as Solaray, available in health food stores. This vet recommends giving dogs weighing under 15 lbs.-one-quarter of the human dose. Dogs 15 to 50 lbs. can take one-third of the human dose, and larger dogs can take one-half of the human dose. Most dogs will need to take the supplements for the rest of their lives.

Strengthen the Nerves with Massage. Back and spinal disk injuries sometimes put pressure on the nerves that control urination, resulting in incontinence. You can use a technique called motion palpation to flex the spine and reduce pressure on the nerves.
---Motion palpation is easy to do. Hold your thumb and index finger together and find the dip between the vertabra on either side of your pet's backbone. Gently press straight down for 1 to 2 seconds, then release. (Some pets are sensitive to the pressure, and you may want to press with the flat of your hand.) Starting at the shoulders and going to the hips, press between each vertabra, using just enough pressure to slightly move the spine. Because motion palpation helps keep the spine flexible, it can be used to help prevent as well as treat incontinence.

Keep the Mind Sharp. Older dogs sometimes lose control because they forget that they are supposed to wait until they get outside. A variety of vitamins, including vitamins A, C, and E, seem to help. This vet recommends using a supplement called Cell-Advance, available from vets, following the directions on the label.
---Digestive enzymes such as Prozyme and FloraZyme, available in pet supply stores, may also help the intestines absorb nutrients more efficiently, which can play a role in keeping the mind sharp. Every pet needs different amounts, so follow the directions on the label.
---An alternative to store-bought enzymes is to give your pet yogurt containing active cultures with every meal. Pets under 15# can have a few teaspoons, and larger pets can have a few tablespoons. (Corky/Max: I have read elsewhere that human yogurt does no good as a dog needs different kind of active cultures! So you decide!!)
---Egg yolks also act as natural digestion enzymes. Pets under 50# can have 1 egg yolk a week, and larger pets can have 2. (Corky/Max: I assume the vet is talking about raw egg yolks! And on another note--My 2 dogs get a raw egg yolk almost every morning in their breakfast---Cholesterol is not a problem in dogs unless there is some other individual problem where egg yolks would be bad for them! Eggs are the most complete protein there is and very good for the dog---esp. good for the coat also.)
This is 1 dog owner's Experience:
Judith wasn't happy when Jill, her poodle companion of 14 yrs, began dribbling urine in the house, but she wasn't about to let a damp carpet get in the way of their wonderful relationship. So she took Jill to a conventional vet, who prescribed synthetic estrogen to be given every day.
---Judith faithfully gave the medication for 3 mons. Jill's control did improve, but the medicine was making her sick. (Corky/Max: And this was not even Proin--which prob. wasn't in use for dogs 10 yrs. ago!) She wouldn't eat, she was bloated, and generally didn't feel very well. "Jill had all the signs of estrogen overdose when I saw her," says this holistic vet.
---The holistic vet stopped the estrogen and started treating Jill with digestive enzymes and herbal supplements, along with a procedure called aquapuncture, in which dilute substances, including vitamin B12, are injected near acupuncture points.
---The treatments worked, and within just a few weeks Jill was both dry and healthy, and she quickly regained her usual energy. This is the end from this book. May have a few more comments when I go through some of my other books---But enough for a while. Hope some of this is doable. One comment for now. I have noted in several of my books that crappy commercial dog food may contribute to this problem and getting your dog on better nutrition may help the problem but whether it is too late to stop the problem or not-?--Point being --If the dog had never been on crappy unhealthy dog food in the 1st place--may never have developed the problem in the 1st place! Proper nutrition makes for a Healthy dog!!!