[jenkyaecho]

Both my female GSD's are on Proin...
One is on 75mg 3 times a day, the other is on 50mg 1- 1/2 pills a day. They both seem to be perfectly fine. No side effects. The one on 50 mg has been on Proin for 8+ years... she is now 10 years old. My other girl on the 75 mg 3x's a day has been on Proin for about 3 1/2 years, with no issues, she is 5 years old. It's sad to hear of all the issues on here... But it must be a case by case thing?

[Todd]

Originally Posted by jenkyaecho

Both my female GSD's are on Proin...
One is on 75mg 3 times a day, the other is on 50mg 1- 1/2 pills a day. They both seem to be perfectly fine. No side effects. The one on 50 mg has been on Proin for 8+ years... she is now 10 years old. My other girl on the 75 mg 3x's a day has been on Proin for about 3 1/2 years, with no issues, she is 5 years old. It's sad to hear of all the issues on here... But it must be a case by case thing?

Here's how I like to think of these things. I have no doubt that certain meds like Proin can be very dangerous. Smoking can be dangerous too. Some people die of lung cancer when they're 50 from smoking and a few select others will go on to live to 85 years old after smoking for the better part of their lives. There is no doubt that Proin can be harmful but just because something's harmful doesn't mean it will harmfully effect every single individual dog. I personally wouldn't take any risks because you never know when your dog will be one of those statistics. Using more doses than necessary is another story but I would try to avoid thia stuff all together and try some alternative therapys. I'd only use this as a "last resprt".

[cherylmartin]

Todd, I agree with you this time.

If I knew then what I know now, I would NEVER have given Jasmine Proin, for this is what killed her. If I had been given a Client Information Sheet (or knew they existed for pet meds) I would have never given it to her, would have asked for alternatives or just lived with her problem. Jasmine had a pre existing condition (heart murmur) and should never had been allowed to take this drug. The vets made a mistake in prescribing this for her, but no "authority' agrees with me. But I know what killed Jasmine.

Like Rimadyl, ProIn can cause death in pets. They took Dexatrim off the market and all other products containing ingredients that caused heart attacks in young women-they should take this and all other meds that have this ingredient for pets off the market as well.

Visit my Jasmine at: Jasmine's Rainbow Residency at RainbowsBridge.com

And help spread the word that ProIn and other drugs can kill. And as pet owners we should research anything before we give it.

Cheryl and Angel Jasmine

[cherylmartin]

To Those Who Complained About ProIn:

I requested from the FDA a FOIA report regarding ProIn.
They sent me only one case MINE!!
How can this be true?? Did no one in this forum report to the FDA that there is a problem with ProIn? Did no one in this forum report to Pegasus Lab that there is a problem with ProIn?
How can you profess to be furbaby lovers/parents and not do anything when another drug is killing our beloved pets?? Rimadyl losses are noted at FDA-why not ProIn.
I do not understand.
Wake up people and do something about this drug.

Cheryl and Angle Jasmine

[CorkyMax]

Originally Posted by cherylmartin

To Those Who Complained About ProIn:

I requested from the FDA a FOIA report regarding ProIn.
They sent me only one case MINE!!
How can this be true?? Did no one in this forum report to the FDA that there is a problem with ProIn? Did no one in this forum report to Pegasus Lab that there is a problem with ProIn?
How can you profess to be furbaby lovers/parents and not do anything when another drug is killing our beloved pets?? Rimadyl losses are noted at FDA-why not ProIn.
I do not understand.
Wake up people and do something about this drug.

Cheryl and Angle Jasmine

Cheryl, I believe there is a problem with Proin and definitely would have complained but I could not because I have never used it and have nothing to 'stand on!'---BUT I would think people who have had a dog die because of this crap would (should) complain!! How else is this stuff going to be forced off the market?!! I wonder also if you were lied to about the FOIA report!! (THis could be lied to from Pegasus Lab or/and the FDA! If anyone reading this thread has had problems with Proin and has filed a report---Please respond so we know if this was a lie or not!! (Could this possibly be a scandal in the making!!?)
I also wonder how many members who have had a dog die from Proin ever come back in this forum after telling of their experience in their one and only post!!?? (Which may be why your previous pleas to get people to report were never seen by many people---But I would think that new people checking the 'net' for answers would be directed to this forum!) Maybe this thread will help! Wouldn't it be something if it could be proven that you were lied to and be able to 'call' them on it!---There just has to be more reports than just yours with the amount of people who have had 'bad' things happen to their dogs because of it!!:-(:-x

[Lara's mom]

As I recall, there were a number of people who had a dog either die or become very ill after taking this drug. Is there any way to check to see if they are still active members? Their screen names would be found on the threads that have been made about the drug.

[CorkyMax]

Originally Posted by Lara's mom

As I recall, there were a number of people who had a dog either die or become very ill after taking this drug. Is there any way to check to see if they are still active members? Their screen names would be found on the threads that have been made about the drug.

Good idea Lara's Mom! I am in process of searching out the members that had problems/deaths with Proin. Of course this is a long old thread--I am only on page 3 of this thread and only 2 members are active so far on these 3 pages. (cannot contact inactive members as you can't go to a profile page for them anymore). Below is an active member you can go to profile page and private message and from the message below, I am sure they will want to know. (Only hope this person will get the private message notification in their email as not sure they get in forum that much recently) The other member I have so far is Ntrep and I can call her as we talk on phone and email. Her dog didn't die but got very sick.


Cheryl, I am going to compile a list of members for you--If you want to contact them!? Will be back with the list as soon as I get it all together.

Here is the copy of this member's post:

07-18-2009 #34 (permalink) - Add Post To Favorites
Bailey24
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Proin 50

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Can I ask where you found the information about seizures? I researched the drug also AFTER our dog died and could not find any conclusive research about seizures. The only place I found cases was on the Doggie chat boards. We too are devestated that we were responsible in part for our dogs death. It breaks our heart everyday. All the vets I have spoken with insist the Proin had nothing to do with her dying, so I would love to know where you found the information that I can share with them.


I just came across another post done by Bailey 24!!!
It sounds to me like Bailey may have filed a report---Cheryl you must contact her/him!!!
07-20-2009 #38 (permalink) - Add Post To Favorites
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Proin 50 - ADE

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Just wanted to share for those pet owners that have had dogs have an Adverse Drug Reaction to Proin - you can file a report with the drug company. They fill out a FDA From 1932 and forward the report to the CVM. The info can be found at http://www.fda.gov/AnimalVeterinary/...ReportsProblem.
This may be an effective way to add other side effects and warnings for the administration of this drug. The company is PRN Pharmacal in Florida.
Maybe this can help save some dogs.


I thought this post you done earlier (Cheryl) might be a good idea to post again in case someone wants to get a hold of you about all this and so they can tell you if they reported the Proin!--->

10-01-2009 #73 (permalink) - Add Post To Favorites
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Don't let their deaths go unnoticed

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Important Information

If you do not file a complaint with the FDA.....
you're giving the manufacturer ammunition to use against you.
They can then claim there are so few cases of adverse reactions.... nothing needs to be done.

When you don't file, you stack the statistics in the manufacturers favor.
Don't depend on your vet's office

I saw this: FDA Suspect ADE )
while searching other forums. Corky/Max talking here: The above link won't work--FDA Suspect ADE--to do with me recopying it but this is the link that will work:FDA Suspect ADE

PLEASE if your pet has had an adverse reaction to ProIn or any other drug , contact the FDA. If you don't, the drug companies win. Do it for your lost baby.

If you want further info on how to do this, just email me.


Here are 2 more posts that sound like they reported on Proin! Read post #85 done before this post (same person)

10-18-2009 #87 (permalink) - Add Post To Favorites
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Thank you for your kind thoughts--I'm so sorry for your loss.
I am definitely going to make some noise over this--your link on reporting adverse effects to the FDA is very helpful, and we'll certainly be reporting this.


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10-18-2009 #88 (permalink) - Add Post To Favorites
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Proin is POISON!

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My daughter “Morag” posted a message about our greyhound Twiggy and her adverse reaction to Proin. Twiggy and her sister grey, Brandy went to the vet for what I thought was bladder infection-- in one of the greys. The vet suggested he treat both dogs for infection and said it was perfectly safe to do that. (STUPID ME!) Anyhow, within 24 hours of taking the drug Twiggy was near death and she died shortly there after.

Twiggy had only 2 doses of Proin. When I got her to the “new” vet who treated her after she ‘crashed’ from the Proin--the vet carried her into the vet hospital and Twiggy wagged her tail briefly at me--the vet told me that he thinks that she was ‘stroking’ when I got her to him and that an hour after her arrival she went from bad to horrifically worse.

The doctor had to sedate her because she was in so much pain. She got an auto immune blood disorder from the side effects which caused her blood vessels to rupture hence the vet was unable to get a blood test reading on her. The vet said that her blood was so thick and black because she was terribly dehydrated. In Morag’s posting above she mentioned some of the other side effects Twiggy suffered from.

Thankfully our other grey did not take the Proin as she refused it and I would not force her to take it. Twiggy took it like it was candy and that image will be forever etched in my mind. Many people have their dogs on this drug and it helps them but people need to know that truth about this drug--to the dog who has adverse reactions it is certain death and it is a very, very painful death that no animal deserves to suffer. If my family and I can reach one pet owner and save a dogs life by preventing them giving this to their beloved pet then Twiggy’s death will not have been in vain. I believe Proin is poison and Twiggy’s senseless death couldn’t be a more clear-cut case for Proin removed off the market. Thanks for reading.

[CorkyMax]

You can go to the post #s in this thread of each of these members to click on their username which will bring you to their profile page so you can contact them by private messaging them and a couple have also given their email address as well--which would be a sure way for them to get your message. All have private message as a way of contact--I will note email of the few that have it!
tana--post# 50--8/27/09----dog died

aussiedog08--post# 51 & 53--9/25/09----dog sick

CadburyMum--post# 65--9/25/09----dog sick--EMAIL

Vajia--post# 76--10/10/09------dog sick

morag (I pasted 1 or 2 of her posts above but has this post also--the dog died in this post)--post# 85--10/18/09--EMAIL (The other post I pasted above is #87)

Twiggy-- I pasted her post above too--She is the mother of morag! One of Twiggy's dog died too!--post# 88---EMAIL

redfox--post# 123--1/23/10----dog's blood pressure up after on Proin

emilywednesday--post# 128--1/24/10----dog sick

terrioconnell--post# 133--3/4/10---dog died

[CorkyMax]

[B]10-22-2009 #92 (permalink) - Add Post To Favorites
franticfitz Go to page 10 of this thread--post #92 and click on the username (franticfitz) Profile page has private message as way of contact!----dog died.
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Poor Mr. Merc

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I just lost my 3 year old Greyhound to Proin.

He was prescribed Proin because we had been having recurring problems with him urinating extremely slowly, and also constantly leaking. Other than these two issues, he was as healthy as could be. We had a couple urinary analysis done, one with a catheter and neither of them came back as having an issue. We also had x-rays done to see if there was any sort of blockage such as kidney stones, but nothing was found either. They gave us some anti-inflammatory drugs to try out, but these did not help. So, after a couple months of dealing with him leaking everywhere we asked if there was anything else that could help, so they gave us the Proin.

We came home after the vet visit and gave him 1 Proin and took him on a short walk. After that I fed him his dinner and watched tv with him on the couch. He got up it looked like he was having hiccups. I came over to him and he was a little bit cold. I then decided to take him to the vet we got our prescription from to have him checked out. They were closed by the time we got there. He seemed to be doing ok at that point, no more hiccups and he felt warmer too. So we took him home and declared he was under observation. I kept him on the couch with me and he was comfortable for about an hour. He repositioned a couple times, but nothing out of the ordinary. He then started to pant, but it was a very odd looking pant, a lot more exaggeration with his mouth, and at times it looked like he was trying to throw up but couldn't. We then decided he had to be taken to the vet again to be checked out. I grabbed the leash, but this time he didn't get up. I thought maybe he was tired and so I picked him up and tried setting him on his feet. Nothing but dead weight. I then carried him down to my car and sped him to the nearest emegency vet as it was now around 11:00pm. The closest one to us was 20 minutes away. We made it there and had him rushed into the emegency room. They had to place him on a ventilator because he was not able to push air with his diaphragm, he was strictly pushing air with his mouth. They took x-rays from 3 angles to see if there was any sort of blockage and there wasn't. We told them the only thing out of the ordinary was the Proin. They went through the side effects and called poison control and said they had never heard of a dog losing control of their respiratory system. The company who makes Proin actually picked up the bill for the call to poison control, is this normal or are they just trying to get on my good side? They kept him sedated and on a vent until early the next morning. They removed the tube after he woke up to see if he would start breathing on his own. He didn't, and he still didn't have any control of anything past his neck either. They attempted this one more time in the afternoon, but he still couldn't breath on his own. We had to have him put down to end his suffering.

They told us they could not tell what had caused such a rapid decline. They said it could have been caused by a tick, but they could not find any bites or ticks on him. They said it could have been from some kind of trauma to the neck. They defended Proin as much as they could though. They said by now the effects of Proin should be out of his system. The only thing that points to Proin are his increased blood pressure and heart rate. To me, it had to be Proin, we did nothing out of the ordinary besides giving him that one pill. I've lost my Mr. Mercury and I'll always miss him.


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10-22-2009 #93 (permalink) - Add Post To Favorites
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Oh no! I am so extremely sorry for your loss. I truly am. You are not alone. It is such a tradgey that we continue to lose our babies to ProIn.When you are able, please join in the fight to have this vicious drug taken off the market. Reply here or contact me at my listed email. PLEASE. I can't do this alone.

Cheryl and her Angel Jasmine


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10-24-2009 #94 (permalink) - Add Post To Favorites
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Another senseless death-when will vets wake-up??

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Dear FranticFritz-

I just read your post about the death of your greyhound Mercury, to Proin. I was in your shoes just a week ago when our grey Twiggy died after having 2 doses of Proin. Please know that you truly are not alone.

I have found since Twiggy's death due to Proin that vets easily make excuses and generalizations when it comes to Proin--in fact the very vet who prescribed the drug to Twiggy called me the other day to tell me how sorry he was for our famiy's loss and that he doubted very much if Proin contributed to it! An example of this is right here in this thread - there is a post by a dr.dan1960, who I assume is a vet and refers in his post that the other posts in this thread are nothing more then anecdotal (not necessarily true because not backed by facts.) This arrogant attitude that they know better because they have not seen with their own eye's a dog dying from Proin is frustrating and inexcuseable.

I have relayed to my new vet who cared for Twiggy in the end what my old vet who prescribed the Proin said to me about doubting it had anything to do with her death and he told me he was not surprised at the vets attitude--he also told me that Proin did indeed kill Twiggy - he witnessed the inhumane death that she suffered--thankfully my new vet is willing to research Proin and what happened to Twiggy and try and get the word out to Veterinarians. I told him I don't think that many vets truly care that Proin has this adverse reaction in many dogs and he told me, "They better care, if they are treating dogs they better care about what they give them."

I realize that many vets use this drug and have never seen the adverse reactions that are happening, many of them give it to their own dogs and it works fine, but if vets truly were made aware of the horrific death that this drug can and does cause in many dogs then I would hope they would stop using it.

One would hope that vets are as ethical as any doctor in any profession and that they would, "FIRST DO NO HARM!"

Please go to the site that I paste below-it is a thread I posted in GreyTalk when Twiggy was in the throes of dying from Proin. The posts from other greyhound owners with similar stories is enlightening.

Help! Any Info On The Drug Proin Reaction Needed - Greytalk - Adopted Greyhound Forum. A discussion forum for greyhound dog owners.

http://forum.greytalk.com/index.php?...41212&hl=Proin


Cheryl, The link above also has posts of more people who have had deaths/sick dog because of proin!

[cherylmartin]

May 24, 2010

The Food and Drug Administration’s Center for Veterinary Medicine (CVM) announced today the launch of an upgraded database that enables manufacturers to electronically submit mandatory reports of adverse drug events. CVM is also announcing the availability of revised versions of Forms FDA 1932 and 1932a, “Veterinary Adverse Drug Reaction, Lack of Effectiveness or Product Defect Report".

CVM developed and implemented a pharmacovigilance program that accepts reports electronically and pre-populates CVM’s database for adverse drug events, because electronic submission is a more efficient method of processing the large volumes of adverse event information submitted to CVM. CVM will be able to process information more efficiently and better address issues affecting animal health and safety.

Electronic submission of adverse event information will be possible through CVM’s Electronic Submissions System (ESS), which integrates with the FDA Electronic Submissions Gateway (FDA ESG) to allow adverse drug event reports, either individually or in batches, to be transmitted directly from industry to CVM (i.e., gateway-to-gateway submission).

FDA has also revised the form for mandatory reporting of adverse drug events for manufacturers, Form FDA 1932. A transitional period of approximately six months will allow companies time to accommodate the revisions, as they may require changes to validated databases. During this time, both versions of Form FDA 1932 will be available. After this transitional period, only the revised version of the form will be available for use.

In addition, a revised version of Form FDA 1932a for voluntary reporting of adverse event information from private individuals, consumers, or healthcare professionals is now available.

A draft Guidance for Industry is available with instructions on how to complete Form FDA 1932, regardless of the method of reporting (i.e., paper or gateway-to-gateway submission).

-Additional Information
Veterinary Adverse Event Reporting for Manufacturers1
- Contact UsIssued by: FDA, Center for Veterinary Medicine

240-276-9300
240-276-9115 FAX
Communications Staff, HFV-12

7519 Standish Place

Rockville, MD 20855
-- - Links on this page:Veterinary Adverse Event Reporting for Manufacturers
Page Last Updated: 05/24/2010
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[christinetague]

My 11-y-o female mixed breed was incontinent for two weeks; diapers don't stay on. Within 15 minutes of her first dose of Proin, she was drooling and panting. She had her first seizure three hours later. I rushed her to the emergency clinic, where she crashed -- hematocrit off the charts, fluid in her lungs, bleeding in both eyes, dehydrated. She was euthanized the next morning. Like so many others, I was told this drug has been used for decades and the vet "had never hearf of such a reaction." She was my heart and soul. I went from having an incontinent dog to having a dead dog.

[cherylmartin]

Christine,

My heart aches for you and I am so sorry and sad.

Yet another loss from ProIn. It is so uncesessary. If you had received a Client Information Sheet and allowed to decide what to give her, I believe you would not have done so.

If all those who have lost a beloved furbaby would file a formal complaint against Pegasus Lab and FDA, FDA has to listen to us. But sadly, no one, but myself, has done this follow up.

Please know that you and your beloved furbaby are in my thoughs and prayers today.

Jasmine's Rainbow Residency at RainbowsBridge.com

[Todd]

Originally Posted by christinetague

My 11-y-o female mixed breed was incontinent for two weeks; diapers don't stay on. Within 15 minutes of her first dose of Proin, she was drooling and panting. She had her first seizure three hours later. I rushed her to the emergency clinic, where she crashed -- hematocrit off the charts, fluid in her lungs, bleeding in both eyes, dehydrated. She was euthanized the next morning. Like so many others, I was told this drug has been used for decades and the vet "had never hearf of such a reaction." She was my heart and soul. I went from having an incontinent dog to having a dead dog.

I am so sorry. This med seriously needs to be taken off market. Can't freaking believe it's still on the market. Sounds like another ploy for a quick buck. Very depressing. Just read a dog magazine with a proin add in it. Disgusted me...

[cherylmartin]

Todd,

I've been saying that since Oct 09 when it killed my beloved Jasmine.

Jasmine's Rainbow Residency at RainbowsBridge.com

And do you know what I don't understand: People come here and share their sorrow about their loss, their anger about this drug, how devestated they are, and according to the FDA, I'm the only person who actually HAS filed a complaint with the FDA! It does not cost anything to do this, except time and my Jasmine is worth every minute I spent doing it. Even though I have recenlty adopted/ rescued a schnorkie, I will never give up the fight. I will go to every forum out there trying to convince people to take the time to report and I mean any and all adverse reaction to any and all drugs.

[Todd]

Originally Posted by cherylmartin

Todd,

I've been saying that since Oct 09 when it killed my beloved Jasmine.

Jasmine's Rainbow Residency at RainbowsBridge.com

And do you know what I don't understand: People come here and share their sorrow about their loss, their anger about this drug, how devestated they are, and according to the FDA, I'm the only person who actually HAS filed a complaint with the FDA! It does not cost anything to do this, except time and my Jasmine is worth every minute I spent doing it. Even though I have recenlty adopted/ rescued a schnorkie, I will never give up the fight. I will go to every forum out there trying to convince people to take the time to report and I mean any and all adverse reaction to any and all drugs.

I will file a complaint as well. I will try to do it tonight or tomm...

What would you think about creating a petition?

[cherylmartin]

I'll try anything

[Melknight]

I haven't read through all the posts her, but I read quite a few and I've only seen posts about female dogs on Proin. I have a male dog who was just prescribed this medicine. It seems to be helping his incontinence (though not completely) but these comments are all scaring me. What's the best alternative medicine for incontinence? And is this an appropriate treatment for a male dog at all?

[CorkyMax]

Originally Posted by Melknight

I haven't read through all the posts her, but I read quite a few and I've only seen posts about female dogs on Proin. I have a male dog who was just prescribed this medicine. It seems to be helping his incontinence (though not completely) but these comments are all scaring me. What's the best alternative medicine for incontinence? And is this an appropriate treatment for a male dog at all?

Check out post # 124 (#'s are top right of each post) on page 13 of this thread. I can't off hand answer the question about for male dogs--but if you put words like--proin/male dogs in your browser, you will prob. find an answer. Please don't use proin--Is it worth the risk of killing your dog for such a problem that has nothing to do with the dog not otherwise being healthy!!??:-(:-(

[Melknight]

Originally Posted by Corky/Max

Check out post # 124 (#'s are top right of each post) on page 13 of this thread. I can't off hand answer the question about for male dogs--but if you put words like--proin/male dogs in your browser, you will prob. find an answer. Please don't use proin--Is it worth the risk of killing your dog for such a problem that has nothing to do with the dog not otherwise being healthy!!??:-(:-(

Thanks. Going to look into something else.

[CorkyMax]

Originally Posted by Melknight

I haven't read through all the posts her, but I read quite a few and I've only seen posts about female dogs on Proin. I have a male dog who was just prescribed this medicine. It seems to be helping his incontinence (though not completely) but these comments are all scaring me. What's the best alternative medicine for incontinence? And is this an appropriate treatment for a male dog at all?

Hey! I put those words in my browser I told you to try.
I just picked this link (You can try more if you want--I am pressed for time right now) I give you this with mixed feelings as no matter what is printed here---I still say NO NO to proin. As I said I am in a hurry so just scanned the article but if I read it right--It sounds like another drug for this use is just as bad or maybe worse! To put it bluntly and in a nutshell---I'd rather have a live dog with incontinence then a dead dog-Period! I just had to put my Corky down from heart problems and I'd do just about anything to have him back and healthy. You do not want to lose your dog!

Guess I'm in too much of a hurry--forgot to leave the link:Phenylpropanolmine used in Dogs

Note you posted while I was doing this post so hadn't read your last reply till just now!