I'm not sure why you say amputation isn't an option. If it's just because she's a big dog and the cancer is in a rear leg, I'd put amputation back on the table for consideration.
As the vet I work for is fond of saying, dogs have three good legs and a spare. Amputating a rear leg is less of a problem than amputating a front leg. Most dogs compensate really well, and really quickly, after a rear leg amputation. They're up and running around, acting like nothing's wrong, in short order.
Unless there's a health issue you didn't mention, or the tumor is too far up the leg, I'd amputate if it were my dog.
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