We had a saint bernard that had epilepsy. She had cluster seizures just like you described your dog having. Phenobarbital takes a while to work. Weeks, or even months. Some senior dogs develop it. Your vet should take an ex-ray of your dog's head to make sure there isn't any tumors causing the seizures. Our saint bernard would have cluster seizures for days. Make sure you give your dog it's medication at the same time every day and whatever you do, DO NOT MISS A DOSE! Missing a dose of phenobarbital can trigger seizures. Phenobarbital is precessed in the liver, so drinking water and peeing will increase. Make sure your dog has plenty of water down at all times. If it doesn't have plenty of water to flush the drug out, it can get concentrated in the liver and cause liver failure. If your dog quits drinking water and peeing, take it to the vet immediately. If you see blood in your dog's pee, also take it to the vet. If phenobarb doesn't work after a while, your vet may prescribe potassium bromide. Our dog had seizures while she was on the medication. After her seizures were over, we had to re-housetrain her. It was very hard for us and our dog. You need to tell your vet anything that is happening with your dog, even if you think it's not that important.
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