...great Dane and lab.? They play ruff, she has a slight limp, can i give her Ibuprofen ?? or what to ease the inflammation and how much

I used to give my dog bute, its like ibuprofen for horses. but dont feed too much, 20lb dog 1000lb horse. you get the point.

Dear god no! the only human medication you could give your dog is aspirin and only in small doses for temporary inflamation relief.You haven't said how old she is or on which leg she's limping. If its a joint problem you could try her on something called "Sasha's blend" it's basically glucosamine which is a human medication derived from shark cartilidge for the treatment of arthritis. You should also consider taking her to your vet to have the problem correctly diagnosed.